Digital Livelihoods Undone

Nucleoli come undone

eceptor tyrosine kinases are often regulated by negative feedback loops that limit their signaling duration. But cells then need to get out of that loop so that they can respond once again. One way to balance the scales is a “signaldependent degradation of a negative regulator,” according to Dafna Bar-Sagi. The inducible degradation of the protein hSpry2, a human homologue of the negative regul...

Coming undone at the seams

Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting in altered maturation and increased migration of epithelial cells in the intestine. They were also more likely to develop intestinal, colon, and rectal tumors. The mice are the first good model for studying rectal tumors, which are common in humans. Anticancer lubrication new mouse model for the s...

CITES & Livelihoods

Would you wish the research undone?

SIR — Rose offers a piece of moral advice in his Commentary. To instruct humankind that they should not do something is a serious undertaking: it should be clear what is enjoined and the consequences acknowledged. Rose seems to argue that, by about 1975, it should have been clear to everyone that the question of genetic causes behind the black/white IQ gap was unanswerable. From that date, ther...

Governance and Sustainable Livelihoods